Safety of Concomitant Use of Dexamethasone and Evolocumab

Mechanism and Rationale

• Dexamethasone is a corticosteroid used primarily for anti-inflammatory effects, antiemetic prophylaxis in chemotherapy, and treatment of various hematologic malignancies including multiple myeloma, according to the Mayo Clinic Proceedings and the Journal of the National Comprehensive Cancer Network 1, 2

Clinical Evidence Supporting Safety

• Dexamethasone is routinely combined with multiple other agents in oncology settings (including with bortezomib, lenalidomide, pomalidomide, and daratumumab) without affecting concurrent cardiovascular medications, as reported by the Mayo Clinic Proceedings 1, 3

Important Clinical Considerations

• Monitor for corticosteroid-specific effects such as hyperglycemia, which could theoretically affect cardiovascular risk independent of the Repatha treatment, but this does not represent a drug interaction, as noted by Praxis Medical Insights 4