Management of Lithium and Lurasidone Overdose

Initial Assessment and Management

The American College of Emergency Physicians recommends checking for responsiveness and activating the emergency response system immediately, assessing breathing and pulse for less than 10 seconds, and starting high-quality CPR if the patient is in cardiac arrest 1
The American Heart Association suggests securing the airway and considering endotracheal intubation if respiratory status is compromised 2

The American College of Emergency Physicians advises continuously monitoring vital signs, mental status, and cardiac rhythm 1
The National Institute of Mental Health recommends watching for signs of serotonin syndrome if the patient is on other serotonergic medications 2

The American Academy of Clinical Toxicology recommends patients be observed in a healthcare setting until the risk of recurrent toxicity is low and vital signs have normalized 1
The American Psychiatric Association suggests psychiatric evaluation is essential before discharge to assess suicide risk and adjust treatment plan 3
The American Psychiatric Association recommends considering alternative medication regimens if the overdose was intentional 3

The American College of Emergency Physicians warns against focusing solely on one drug when managing this polysubstance overdose 2
The American College of Emergency Physicians cautions that stable vital signs can deteriorate rapidly in overdose situations 2