Management of Hyperglycemia with SGLT2 Inhibitors

Introduction to SGLT2 Inhibitors

• The American Diabetes Association guidelines support adding an SGLT2 inhibitor like Jardiance to improve glucose control and potentially reduce total daily insulin dose 1

Glycemic Control

• When basal insulin has been initiated but blood glucose levels remain above target, combination therapy with an SGLT2 inhibitor should be considered to improve glycemic control, as recommended by the American Diabetes Association 1

Insulin Adjustment

• Initially, maintain the current Lantus dose and monitor blood glucose closely for 1-2 weeks after starting Jardiance, then may need to reduce insulin dose by 10-20% if blood glucose improves significantly to avoid hypoglycemia, as suggested by the American Diabetes Association guidelines 1

Cardiovascular Benefits

• No cited fact available for this section

Monitoring

• Check blood glucose daily, especially fasting levels, and monitor for symptoms of hypoglycemia, with the goal of reassessing HbA1c after 3 months of therapy, although no specific citation is provided for this fact, it is implied by the context of managing hyperglycemia with SGLT2 inhibitors 1