COPD Treatment with Breztri

Patient Selection and Treatment

• The American College of Chest Physicians notes that for COPD patients, triple therapy is considered appropriate for patients with more severe COPD (GOLD category D) 1
• The American College of Chest Physicians notes that for COPD patients, the number needed to treat is four patients for one year to prevent one moderate to severe exacerbation with triple therapy versus dual bronchodilator therapy 2
• Inhaled corticosteroid therapy may increase the risk of pneumonia in COPD patients, with a number needed to harm of 33 patients for one year to cause one pneumonia, suggesting a favorable risk-benefit ratio 1, 2

Safety and Efficacy

• Initial assessment of COPD severity, exacerbation history, and response to current therapy should be evaluated, considering Breztri for patients with moderate to severe COPD with FEV₁ <50-60% predicted and a history of exacerbations despite optimal bronchodilator therapy 1, 2