Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 11/10/2025

Timolol in Glaucoma Management

Efficacy and Position in Therapeutic Algorithm

  • The American Academy of Ophthalmology considers prostaglandin analogs (bimatoprost, latanoprost, travoprost) as first-line agents, which are more effective than timolol in reducing intraocular pressure (IOP) in patients with open-angle glaucoma and ocular hypertension 1, 2, 3, 4
  • Timolol is effective as monotherapy when prostaglandin analogs are contraindicated or not tolerated, and can be used as a first-line alternative 1, 2, 3
  • The combination of timolol with prostaglandin analogs can achieve additional reductions in IOP, with an additive effect demonstrated 3, 4, 5