Lurasidone Use in Chronic Kidney Disease

Clinical Considerations

• The American College of Physicians suggests that CKD patients have a higher cardiovascular burden and metabolic complications, making lurasidone a valuable option due to its safety profile 1

Psychiatric Care in CKD

• The National Kidney Foundation acknowledges that SSRIs have failed to show consistent benefit in dialysis patients and carry increased gastrointestinal adverse effects 2, 3, 4
• The Kidney International journal notes that no randomized controlled trials exist for pharmacologic management of anxiety in kidney failure populations 2, 3
• General principles for psychotropic prescribing in kidney failure emphasize caution with QTc prolongation and altered pharmacokinetics, which lurasidone's safety profile addresses 3, 5

Nonpharmacologic Approaches

• The American Psychological Association recommends that cognitive behavioral therapy has proven efficacy for reducing depression in dialysis patients 2, 3, 6
• The National Institute of Health suggests that aerobic exercise shows moderate-quality evidence for decreasing depressive symptoms in hemodialysis 2, 3