Enclomiphene Citrate Mechanism and Side Effects

Mechanism of Action and Clinical Considerations

• The European Society of Human Reproduction and Embryology recommends that for ovulation induction, lower doses of enclomiphene citrate should be used to minimize multiple follicular development and reduce multiple pregnancy risk 1, 6
• The American College of Obstetricians and Gynecologists suggests that in women with functional hypothalamic amenorrhea, clomiphene citrate should only be used when there is sufficient endogenous estrogen level 4, 5

Metabolic and Reproductive System Effects

• The American Academy of Family Physicians notes that enclomiphene citrate can alter serum lipid profiles 3
• The American Society for Reproductive Medicine reports that ovarian hyperstimulation syndrome is a potential side effect of enclomiphene citrate, especially with multifollicular development 1, 2

Contraindications and Precautions

• The American Association for the Study of Liver Diseases advises that enclomiphene citrate should be avoided in patients with liver disease, especially those with decompensated cirrhosis 7