Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/29/2025

Unintentional Weight Loss Evaluation

Initial Assessment

  • Assess for symptoms suggesting underlying disease: pain, pulmonary complaints, gastrointestinal symptoms, as recommended by the National Comprehensive Cancer Network 1
  • Screen for psychological factors including depression, anxiety, and eating disorders, as suggested by Obesity Reviews 2

Laboratory Testing

  • Evaluate for diabetes using HbA1c, as recommended by Praxis Medical Insights 3

Special Considerations

  • Conduct a nutritional assessment using validated tools such as MUST, NRS-2002, or SNAQ, as recommended by Praxis Medical Insights 3

REFERENCES

1

survivorship: fatigue, version 1.2014. [LINK]

Journal of the National Comprehensive Cancer Network : JNCCN, 2014

3

Workup for Unintentional Weight Loss [LINK]

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025