Primaquine Prophylaxis Guidelines

Terminal Prophylaxis Regimen

• The Centers for Disease Control and Prevention recommends terminal prophylaxis with primaquine for preventing P. vivax and P. ovale relapses after exposure, with a dose of 15 mg base daily for 14 days 1, 2, 3
• Terminal prophylaxis is particularly indicated for persons with prolonged exposure in endemic areas, such as missionaries and Peace Corps volunteers, according to the Centers for Disease Control and Prevention 1, 2, 3