Recommended Infusion Time for Cefuroxime

Standard Infusion Times by Clinical Context

• The American Society of Anesthesiologists recommends cefuroxime 1.5g as a slow IV infusion for cardiac surgery, with an additional 0.75g in priming solution 1
• The American Society of Anesthesiologists recommends cefuroxime 900mg as a slow IV infusion for thoracic surgery 2
• The American Society of Anesthesiologists recommends cefuroxime 1.5g as a slow IV infusion for orthopedic surgery 3
• The American Academy of Ophthalmology recommends cefuroxime 1mg as an intracameral injection at the end of cataract surgery 1

Re-dosing Guidelines

• The American Society of Anesthesiologists recommends re-injecting 0.75g of cefuroxime every 2 hours intraoperatively for cardiac surgery 1
• The American Society of Anesthesiologists recommends re-injecting 0.75g of cefuroxime for procedures lasting longer than 2 hours to maintain adequate antibiotic levels 1, 2

Special Considerations

• The American Society of Anesthesiologists notes that when vancomycin is used as an alternative in allergic patients, the infusion must last 120 minutes and should end at the latest by the beginning of the intervention, ideally 30 minutes before 1, 4