Dosing Considerations for Fexofenadine in Renal Impairment

Introduction to Renal Impairment

• A GFR of 40 mL/min/1.73m² falls into the moderate renal impairment category (GFR 30-59 mL/min/1.73m²), requiring dose adjustment, as stated by the American Journal of Kidney Diseases 1

Pharmacokinetic Considerations in Renal Impairment

• The KDOQI guidelines emphasize the importance of taking GFR into account when dosing medications, particularly for those primarily eliminated by the kidneys, such as fexofenadine, according to the American Journal of Kidney Diseases 1

Clinical Considerations in Renal Impairment

• During acute illness that may further compromise renal function, temporary discontinuation of renally excreted medications like fexofenadine may be necessary to prevent adverse effects, as noted by the American Journal of Kidney Diseases 1