Laboratory Monitoring for Patients Receiving Mannitol Infusion

Essential Laboratory Parameters to Monitor

• The Kidney International guidelines recommend monitoring serum electrolytes, particularly sodium and potassium, as mannitol can cause significant electrolyte disturbances 1
• The Kidney International guidelines suggest monitoring renal function tests, including blood urea nitrogen (BUN) and creatinine, to monitor for mannitol-induced nephrotoxicity 1
• The Kidney International guidelines advise monitoring acid-base status, including arterial blood gases, to monitor for metabolic disturbances 1
• The Kidney International guidelines recommend monitoring creatine kinase, particularly in patients with crush injuries or rhabdomyolysis 1
• The Hepatology guidelines suggest that routine prophylactic use of mannitol without close laboratory monitoring should be avoided 3