Administration of Lamotrigine Formulations

Formulation Characteristics

• Dissolving tablets are designed to disintegrate rapidly in the mouth without water, making them easier to take for patients who have difficulty swallowing pills 1
• Regular tablets have a standard solid oral dosage form that must be swallowed whole and have slower absorption characteristics 1

Clinical Administration

• For patients who cannot take oral medications temporarily, dissolving tablets provide an important alternative 1, 2
• Dissolving tablets should not be chewed, crushed, or broken and should be placed on the tongue to dissolve 1
• Regular tablets should be swallowed whole with water 1

Contraindications

• Both formulations are contraindicated in patients with previous lamotrigine-induced rash 3, 4