Pravastatin Dosing and Efficacy

Introduction to Pravastatin

• The American College of Cardiology recommends pravastatin 40 mg daily for cardiovascular risk reduction, as studied in clinical trials 1, 2, 3

Efficacy and Safety

• In the PROVE-IT trial, pravastatin 40 mg achieved a median LDL-C of 95 mg/dL, compared to 62 mg/dL with high-dose atorvastatin, with no cases of severe myopathy (rhabdomyolysis) observed 2
• High-intensity statins, including high-dose pravastatin, may modestly increase the risk of new-onset diabetes, particularly in patients with two or more components of metabolic syndrome 4, 5

Clinical Decision-Making

• When selecting pravastatin dose, consider the patient's cardiovascular risk profile, as recommended by the American College of Cardiology 3, 6