Autoantibody Testing in Multiple Sclerosis

Interpretation of ANA Test Results

• A positive ANA at titers ≥1:80 has relatively low specificity (74.7%) for systemic autoimmune diseases, according to the American College of Rheumatology 1
• Using a higher cut-off of 1:160 improves specificity to 86.2% while maintaining appropriate sensitivity (95.8%) for systemic autoimmune diseases, as recommended by the American College of Rheumatology 2