Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 11/6/2025

Management of Complicated Skin and Soft Tissue Infections

Antibiotic Therapy

  • The Infectious Diseases Society of America recommends empirical coverage with vancomycin IV, linezolid 600 mg twice daily, daptomycin 4 mg/kg/dose IV once daily, or clindamycin 600 mg IV/PO three times daily for complicated skin and soft tissue infections 1