Bupropion Classification and Effects

Pharmacological Profile

• Bupropion is considered weight-neutral or weight-loss promoting, unlike many other antidepressants that cause weight gain, as noted by the American Gastroenterological Association 1
• The medication can cause activation of anorexigenic neurons in the hypothalamus, but this effect is weaker than with traditional stimulants, according to the American Gastroenterological Association 2

Pharmacokinetic Considerations

• The extended-release formulations of bupropion further moderate any stimulant-like effects by providing gradual drug delivery, as reported in Gastroenterology 2