Promethazine DM Weight-Based Dosing in Pediatrics

Contraindications and Warnings

• The American Academy of Pediatrics recommends that promethazine is absolutely contraindicated in children under 2 years of age due to fatal respiratory depression risk, and this contraindication applies to all formulations and indications 1
• The FDA warns that promethazine should be avoided in children with respiratory compromise or those receiving other respiratory depressants, as the respiratory depression risk is particularly concerning when combined with other sedating medications 1