Armodafinil Dosage and Safety Considerations

Special Populations

For elderly patients, consideration should be given to using lower doses (starting at 100 mg) with close monitoring, as recommended by the American Academy of Sleep Medicine 1
Armodafinil is contraindicated in pregnancy based on animal data showing potential fetal harm, though human data are insufficient to determine risk, according to the American Academy of Sleep Medicine 2, 3
The medication may reduce the effectiveness of oral contraceptives, necessitating alternative birth control methods, as suggested by the American Academy of Sleep Medicine 2, 3

The American Academy of Sleep Medicine suggests armodafinil as a treatment option for narcolepsy in adults (conditional recommendation) 2, 3

Armodafinil is an FDA Schedule IV controlled substance due to its potential for abuse or dependency, as reported by the American Academy of Sleep Medicine 2, 3
A 2018 report from the armodafinil/modafinil pregnancy registry showed higher rates of major congenital anomalies in children exposed to the drug in utero, according to the American Academy of Sleep Medicine 2, 3

The medication may reduce the effectiveness of hormonal contraceptives, necessitating alternative birth control methods, as suggested by the American Academy of Sleep Medicine 2, 3