Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/1/2025

Headache as a Side Effect of Intuniv (Guanfacine)

Clinical Considerations

  • The National Comprehensive Cancer Network guidelines note that headache is a common adverse event in the general population and can occur with many medications 1
  • When assessing headache in patients taking guanfacine, it is essential to consider other potential causes of headache, as recommended by the National Comprehensive Cancer Network guidelines 1

Management of Headache with Intuniv

  • Standard headache treatments, such as acetaminophen or NSAIDs, may be used to manage headache in patients taking guanfacine, if not contraindicated, according to the Annals of Internal Medicine 2