Management of Elevated Procalcitonin in Patients with Chronic Kidney Disease

Diagnostic and Treatment Considerations

• The National Kidney Foundation recommends adjusting antibiotic dosing based on kidney function, as patients with chronic kidney disease may require modified dosing regimens 1

Long-term Management Considerations

• The Kidney International guideline suggests implementing a comprehensive treatment strategy to reduce CKD progression and associated complications in CKD patients with recurrent infections, including lifestyle modifications, optimal blood pressure control, and appropriate medication management 2
• The Kidney International guideline also recommends considering nephrology referral based on kidney failure risk assessment, particularly if 5-year kidney failure risk is 3-5%, to address modifiable risk factors and slow CKD progression 3