Mirabegron and Tamsulosin Combination Therapy for Urinary Symptoms

Efficacy of Combination Therapy

• The European Association of Urology recommends combination treatment of an α1-blocker with mirabegron in patients with persistent storage LUTS after treatment with α1-blocker monotherapy 1
• Combination therapy with mirabegron and tamsulosin demonstrates superior efficacy compared to tamsulosin monotherapy in reducing overactive bladder symptoms in men with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) 1

Safety Considerations

Urinary Retention Risk

• The European Association of Urology guidelines do not recommend combination therapy in men with a post-void residual volume >150 mL 1

Clinical Application

• Consider mirabegron add-on therapy for men with persistent storage symptoms (urgency, frequency, nocturia) despite adequate treatment with tamsulosin 1
• Monitor post-void residual volume, especially in men with elevated baseline values 1

Special Considerations

• Combination therapy is particularly beneficial for men with moderate-to-severe storage LUTS 1