Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/23/2025

Clinical Significance of C-peptide in Insulin Production

Diagnostic Value of C-peptide

  • Low or undetectable levels of plasma C-peptide are indicative of little or no insulin secretion, as seen in advanced type 1 diabetes 1
  • C-peptide measurements help distinguish between type 1 and type 2 diabetes in ambiguous cases 2