Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 6/16/2025

Vaccine Coverage and Associated Factors

Introduction to Vaccine Coverage

  • The lack of availability of biological products (vaccines) is the primary factor associated with vaccination failures in children under 2 years, as demonstrated by the statistically significant association found in the mentioned study 1
  • Interruptions in vaccine supply represent a significant problem affecting infant vaccination coverage, with multiple vaccines experiencing shortages in recent years, including Hib, hepatitis B, influenza, and others, leading to missed immunization opportunities 2
  • These interruptions can last for extended periods, leaving cohorts of children without completing their vaccination schedule 2

Barriers to Vaccination

  • The high cost of acquiring, storing, and administering vaccines represents a significant barrier to complete vaccination, according to the American Academy of Pediatrics 2
  • Vaccine distribution systems are poorly integrated, affecting availability in different regions, as reported by the Centers for Disease Control and Prevention 2
  • The time and means of transportation required to reach health centers are significantly associated with incomplete vaccination, although this fact is not supported by a reference in this context

Parental Factors and Vaccination

  • 54% of parents express concern about serious adverse effects of vaccines, which may influence the decision to vaccinate, as found by the American Academy of Pediatrics 3
  • Inconsistent or non-urgent recommendations by healthcare providers are one of the major challenges for immunization, as stated by the American Academy of Pediatrics 3

Consequences of Incomplete Vaccination

  • Up to 80% of pediatric deaths associated with influenza have occurred in unvaccinated or incompletely vaccinated children, highlighting the importance of complete vaccination, according to the Centers for Disease Control and Prevention 4

Strategies for Improvement

  • Implementing reminder/recall systems for children with delayed vaccinations will be easier with the adoption of electronic health records, as recommended by the American Academy of Pediatrics 2
  • Strengthening personal contact between informed, attentive, and concerned pediatricians and parents is crucial for improving vaccine acceptance, as emphasized by the American Academy of Pediatrics 1