Timing of SGLT2 Inhibitor Initiation After Coronary Artery Bypass Grafting

Rationale for Timing

• Current guidelines do not specifically address the timing of SGLT2 inhibitor initiation after CABG, but several principles can guide clinical decision-making, according to the American Heart Association 1, 2

Considerations for Medication Management After CABG

• Beta-blockers should be reinstituted as soon as possible after CABG in all patients without contraindications, as recommended by the American College of Cardiology 3, 4
• ACE inhibitors and ARBs should be reinstituted postoperatively once the patient is stable, as recommended by the American College of Cardiology 3, 4
• Statins should be continued or initiated for all CABG patients without contraindications, according to the American Heart Association 5
• Antiplatelet therapy with aspirin should be initiated within 6 hours postoperatively if not started preoperatively, as recommended by the American College of Cardiology 5