Recurrent Pregnancy Loss Causes and Factors

Genetic and Endocrine Factors

• Some patients with recurrent complete hydatidiform moles have an autosomal recessive condition called familial recurrent hydatidiform mole (FRHM) with mutations in NLRP7 and KHDC3L genes 1
• Diminished ovarian reserve may be associated with increased miscarriage risk, particularly with severely reduced AMH levels (2)

Thrombophilias

• Certain thrombophilias may increase risk of pregnancy loss 3
• Women with homozygous factor V Leiden or prothrombin 20210A mutation with positive family history for VTE should receive antepartum prophylaxis with prophylactic or intermediate-dose LMWH 3