Valproate Therapy in Children

Seizure Management and Valproate Dosing

• The American Academy of Emergency Medicine recommends seizure management protocols and valproate dosing strategies for children, with therapeutic valproate plasma levels ranging from 50-100 μg/mL 1, 2
• The American Academy of Emergency Medicine also notes that some evidence supports valproate plasma levels up to 200 μg/mL in refractory cases, although this is not directly related to SGOT levels 1

Adverse Effects of Valproate

• The American Academy of Pediatrics notes that common adverse effects of valproate include tremor, with an incidence of 20-40%, and gastrointestinal symptoms 4

Normal AST Values in Children

• The American Academy of Pediatrics notes that normal pediatric AST (SGOT) values typically range from 25-75 U/L in newborns 1
• The American Academy of Pediatrics also notes that normal pediatric AST (SGOT) values typically range from 10-40 U/L in adolescents 1