Isotretinoin Treatment Guidelines

Pharmacology and Mechanism

• Isotretinoin reduces sebaceous gland size, decreases sebum production, inhibits sebaceous gland differentiation, normalizes keratinocyte keratinization, and possesses anti-inflammatory properties, as recommended by the American Academy of Dermatology 1

Indications and Usage

• Isotretinoin is the only FDA-approved treatment for severe recalcitrant nodular acne vulgaris, as stated by the American Academy of Dermatology 1

Adverse Effects and Monitoring

• Common adverse effects of isotretinoin involve the mucocutaneous, musculoskeletal, and ophthalmic systems, according to the American Academy of Dermatology 1, 2
• Laboratory monitoring during isotretinoin treatment should include liver function tests, fasting lipid panel, and pregnancy tests for patients with pregnancy potential, as recommended by the American Academy of Dermatology 1, 2