Effects of Amphetamine on Sperm Quality and Fertility

Clinical Considerations and Recommendations

The American Urological Association (AUA) and American Society for Reproductive Medicine (ASRM) acknowledge that recreational drugs can negatively impact fertility, according to the American Society for Reproductive Medicine guidelines 1
The WHO guidelines on male infertility strongly recommend that men trying for pregnancy should abstain from recreational drugs, as these substances may adversely affect semen quality and fertility 2, 3
When evaluating male fertility concerns, clinicians should obtain a comprehensive medication and substance use history, including both prescription and recreational drugs, as recommended by the American Society for Reproductive Medicine 1
Standard semen analysis remains the cornerstone of evaluation for men concerned about fertility impacts of amphetamine use, according to the American Society for Reproductive Medicine guidelines 1

The WHO guidelines note that large-scale prospective multi-center trials are needed to examine the effects of recreational drug use on spermatogenesis, semen quality, and fertility outcomes, highlighting the need for further research by the World Health Organization 4
Most available research focuses on semen parameters rather than actual fertility outcomes such as pregnancy rates or live births, as noted by the World Health Organization 2, 4