Cotrimoxazole-Induced Pancreatitis Mechanism and Risk Factors

Metabolic Effects and Pancreatitis Risk

• Elevated triglycerides (>12 mmol/L) are a known risk factor for pancreatitis development, and cotrimoxazole may induce alterations in lipid metabolism, potentially leading to hypertriglyceridemia in susceptible individuals 1, 2
• The drug might interfere with triglyceride clearance mechanisms, although this pathway is less established than the hypersensitivity mechanism 3, 4