Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 11/7/2025

Recommended Site for Intramuscular Promethazine Administration

Anatomical Sites for Intramuscular Promethazine Administration

  • The Centers for Disease Control and Prevention, as reported in MMWR Recommendations and Reports, recommends the deltoid muscle as the preferred site for intramuscular promethazine in adults and older children, and the anterolateral aspect of the thigh (vastus lateralis muscle) as the preferred site for infants and young children 1
  • The American Academy of Pediatrics, as aligned with MMWR Recommendations and Reports, suggests that the vastus lateralis muscle is the preferred site for infants and young children due to its low risk of vascular or nerve damage 1