Diagnostic and Management Guidelines for Systemic Lupus Erythematosus Presenting with a Transient “Butterfly” Rash

Clinical Assessment

Laboratory Evaluation

Systemic Manifestations

Therapeutic Management

Long‑Term Monitoring

Differential Diagnosis of Malar Rash Using Nasolabial Fold Sparing

Key Differentiating Conditions

• Erythematotelangiectatic rosacea commonly involves the nasolabial folds and presents with malar erythema plus telangiectasias, whereas the malar rash of systemic lupus erythematosus characteristically spares the nasolabial folds. 6
• Seborrheic dermatitis prominently affects the nasolabial folds, providing a contrast to the nasolabial‑fold‑sparing malar rash seen in systemic lupus erythematosus. 6
• Contact dermatitis and other inflammatory facial dermatoses frequently involve the nasolabial folds, helping clinicians distinguish them from the lupus‑associated malar rash that spares these folds. 6