Tadalafil Dosing and Efficacy for Erectile Dysfunction

Adverse Effects and Safety Considerations

• Most frequent adverse events include headache, dyspepsia, back pain, flushing, nasal congestion, and myalgia, with adverse event rates following a dose-response pattern, with higher doses producing more side effects 1
• Serious adverse events occur in less than 2% of patients, with no significant difference from placebo 2

Clinical Recommendations

• Instruct patients that sexual stimulation is necessary for the medication to work, and consider testosterone supplementation if testosterone deficiency is present, as combination therapy is more effective than PDE5 inhibitors alone 1, 3