Weight Loss with Zepbound and Antidepressants

Medication Interactions and Effects

Sertraline is weight-neutral with long-term use, showing minimal weight changes over extended treatment periods, according to the American Gastroenterological Association 1, 2
Bupropion consistently promotes weight loss through appetite suppression and reduced food cravings, making it the only antidepressant that actively supports weight reduction, as recommended by the American Gastroenterological Association 1, 2
Bupropion causes mean weight loss of 2.77 kg at 6-12 months, as reported by the American College of Physicians 3
Zepbound (tirzepatide) is a GLP-1/GIP receptor agonist that works through completely different mechanisms than antidepressants, with no known interactions, according to the American Gastroenterological Association 4

Gastrointestinal side effects from Zepbound, such as nausea and delayed gastric emptying, may be more noticeable initially but typically improve with gradual dose titration, as noted by the American Gastroenterological Association 4
The combination of bupropion and sertraline is ideal for someone pursuing weight loss, as it avoids weight-promoting agents, according to the American Gastroenterological Association 1, 2
Weight loss from this combination should be monitored regularly, as the combined effect of bupropion's appetite suppression and tirzepatide's satiety enhancement could produce more substantial weight loss than either alone, as recommended by the American Gastroenterological Association 1, 4