Oral Treatment for Yeast Infection

Treatment Algorithm for Vaginal Yeast Infections

For moderate to severe cases of oral candidiasis (thrush), fluconazole 100-200 mg daily for 7-14 days is recommended, as per the Infectious Diseases Society of America guidelines 1
For fluconazole-resistant species, such as C. glabrata and C. krusei infections, alternative treatments are required, as these species may be resistant to fluconazole, according to the Infectious Diseases Society of America guidelines 1
For fluconazole-refractory disease, itraconazole solution 200 mg once daily or posaconazole suspension 400 mg twice daily for 3 days then 400 mg daily for up to 28 days can be considered, as per the Infectious Diseases Society of America guidelines 1
Voriconazole 200 mg twice daily is another alternative for fluconazole-refractory cases, as recommended by the Infectious Diseases Society of America guidelines 1
The echinocandins (caspofungin, micafungin, anidulafungin) are generally reserved for systemic fungal infections rather than vaginal candidiasis, according to the Infectious Diseases Society of America guidelines 2

Failure to identify non-albicans Candida species that may be resistant to fluconazole can lead to treatment failure, as noted by the Infectious Diseases Society of America guidelines 1
Not considering underlying conditions (diabetes, immunosuppression) that may require longer treatment courses is a common pitfall, as per the Infectious Diseases Society of America guidelines 1
Not addressing predisposing factors that may lead to recurrence of infection is crucial, as recommended by the Infectious Diseases Society of America guidelines 1