Causes of Jaundice

Etiology of Jaundice

Malignancy is documented as one of the most common causes of jaundice, particularly severe jaundice, according to the American College of Radiology 1, 2
European studies identify malignancy as the most common etiology of severe jaundice, as reported by the American College of Radiology 1, 2
In U.S. studies, malignancy accounts for 6.2% of all jaundice cases, according to the American College of Radiology 2

Impaired bilirubin conjugation is a recognized pathophysiological mechanism causing unconjugated hyperbilirubinemia, as stated by the American College of Radiology 2, 3
Liver disorders, such as hepatitis, alcoholic liver disease, and cirrhosis decompensation, can cause jaundice, with a frequency of 16% and 20.5%, respectively, as reported by the American College of Radiology 1, 2
Bile duct disorders, including choledocholithiasis and cholangiocarcinoma, can cause jaundice, according to the American College of Radiology 1, 2
Pancreatic disorders, such as pancreatitis and pancreatic malignancy, can cause biliary obstruction and jaundice, as stated by the American College of Radiology 1, 2
Hemolysis produces unconjugated hyperbilirubinemia through bilirubin overproduction, accounting for 2.5% of jaundice cases in U.S. studies, according to the American College of Radiology 1, 3