Intrathecal Colistin Administration Guidelines

Dosing and Equivalence

• One million international units (IU) of colistin is equivalent to 80 mg of colistimethate sodium (CMS) 1

Safety and Monitoring

• Renal function should be monitored during colistin therapy, even when administered intrathecally, as some systemic absorption may occur 2

Comparison with Systemic Administration

• Standard systemic dosing for colistin is insufficient for treating CNS infections without direct intrathecal administration, as supported by the Infectious Diseases Society of America and other guideline societies 2, 3