Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 1/12/2026

Management of Seasonal Allergies

Seasonal Allergies Management

  • Intranasal corticosteroids are the most effective medication class for controlling all four major symptoms of allergic rhinitis (sneezing, itching, rhinorrhea, and nasal congestion) in patients with seasonal allergies, according to the American College of Physicians 1, 2, 3
  • Monotherapy with an intranasal corticosteroid is strongly recommended over combination therapy with an oral antihistamine for initial treatment of seasonal allergic rhinitis, with high-quality evidence supporting its effectiveness 1, 4
  • The American College of Physicians and Joint Task Force on Practice Parameters found high-quality evidence supporting intranasal corticosteroids as more effective than oral antihistamines or leukotriene receptor antagonists for patients with seasonal allergic rhinitis 2, 5
  • Second-generation oral antihistamines like loratadine (Claritin) are effective for symptom relief with less sedation than first-generation options in patients who prefer oral medication 3
  • For moderate to severe seasonal allergic rhinitis, combination therapy with intranasal corticosteroid and intranasal antihistamine may be considered, although the evidence is weak 2, 6
  • Adding an oral antihistamine to an intranasal corticosteroid has not been proven to provide additional benefit for nasal symptom control in patients with seasonal allergies 1, 7
  • Avoid using oral corticosteroids for routine management of allergic rhinitis; they should be reserved for severe, intractable cases unresponsive to other treatments, as recommended by the American College of Physicians 3
  • Do not assume that combination therapy is always superior to monotherapy; evidence shows intranasal corticosteroid alone is often sufficient for patients with seasonal allergic rhinitis 1, 7

Seasonal Allergic Rhinitis Management

Introduction to Guidelines

  • The Joint Task Force on Practice Parameters recommends against using intramuscular Kenalog for routine management of seasonal allergic rhinitis, instead suggesting intranasal corticosteroid formulations as first-line therapy, due to their superior efficacy and safety profile 8, 9, 10, 11
  • Intranasal triamcinolone acetonide is the most effective medication class for controlling symptoms of allergic rhinitis, with high-quality evidence supporting its use as first-line monotherapy, according to the Joint Task Force on Practice Parameters 8
  • For patients with moderate-to-severe symptoms, adding an intranasal antihistamine to intranasal corticosteroids is recommended, rather than escalating to systemic therapy, as suggested by the Joint Task Force on Practice Parameters 10
  • Oral second-generation antihistamines can be used as adjuncts to intranasal corticosteroids, although their added benefit is not well established, according to the Joint Task Force on Practice Parameters 12

Intranasal Corticosteroid–Based Management of Seasonal Allergic Rhinitis in Adolescents

First‑Line Intranasal Corticosteroid Therapy

Escalation to Combination Intranasal Therapy

REFERENCES

3

Treatment of Severe Allergic Rhinitis with Prednisone [LINK]

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025