Methylphenidate Therapy and Associated Side Effects

Introduction to Methylphenidate

• Methylphenidate is used for the treatment of narcolepsy and idiopathic hypersomnia in adults, as recommended by the American Academy of Sleep Medicine 1
• Methylphenidate is used off-label for cancer-related fatigue, as suggested by the National Comprehensive Cancer Network 2, 3

Common Side Effects of Methylphenidate

• Methylphenidate use is associated with cardiovascular side effects, including hypertension, palpitations, and arrhythmias, according to the National Comprehensive Cancer Network 2
• Methylphenidate use is associated with neuropsychiatric side effects, including agitation, insomnia, confusion, psychosis, tremor, and headache, as reported by the National Comprehensive Cancer Network 2

Management of Methylphenidate Side Effects

• Adjusting methylphenidate dosing schedule, such as using Concerta which provides 12-hour coverage with once-daily dosing, may be considered to manage side effects, as suggested by Praxis Medical Insights 4