AASM Guidelines on Antidepressant Use for Restless Legs Syndrome

Recommendations Against Antidepressants

• The American Academy of Sleep Medicine (AASM) 2025 clinical practice guidelines state that antidepressants are not recommended as standard therapy for Restless Legs Syndrome and specifically advise against using bupropion, carbamazepine, clonazepam, and valproic acid for RLS treatment. 1, 2, 3