Physiologic Changes with Phenylephrine Infusion in Tetralogy of Fallot

Clinical Implications

• Phenylephrine is an appropriate intervention for hypercyanotic spells in tetralogy of Fallot when morphine and fluid therapy have failed, as recommended by the American Academy of Pediatrics 1
• The increased systemic vascular resistance from phenylephrine forces more blood through the pulmonary circulation, which is particularly beneficial in patients with infundibular spasm, according to the American Heart Association 1