Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/10/2025

Weight Gain Associated with Antipsychotic Medications

Comparison to Other Antipsychotics

  • Atypical antipsychotics as a class are associated with weight gain, but the risk varies significantly between agents, according to the American Medical Association 1
  • Among antipsychotics, olanzapine, clozapine, quetiapine, and risperidone are consistently associated with more significant weight gain, as reported by the American Gastroenterological Association 2