Doxepin Safety in Renal Impairment

Introduction to Doxepin Renal Safety

• Unlike medications that require complex renal dose adjustments, doxepin's hepatic metabolism makes it a simpler option for patients with kidney disease 1

Considerations for Other Medications

• All opioids should be used with caution at reduced doses and frequency in renal impairment, with fentanyl and buprenorphine being the safest choices in chronic kidney disease stages 4-5, as recommended by the European Society for Medical Oncology 2, 3