Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 11/22/2025

Glucagon Injection Guidelines

Site Selection and Administration

  • Truncal sites like the buttocks may be preferable to limb sites based on injection technique principles, as they have thicker subcutaneous tissue, providing a larger margin of safety, according to the American Diabetes Association 1, 2, 3
  • The American Association of Clinical Endocrinologists recommends avoiding injecting into areas with lipohypertrophy, scars, or damaged tissue, as absorption will be unpredictable, for any subcutaneous medication including glucagon 1, 2, 3, 4, 5

Expected Response and Dosing