Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 11/24/2025

Arterial Ulcer Characteristics

Key Distinguishing Features of Arterial Ulcers

  • Arterial ulcers occur in distal extremities (toes, feet, heels) due to inadequate perfusion from proximal arterial stenosis or occlusion, according to the American College of Cardiology 1
  • The American College of Cardiology recommends that arterial ulcers are NOT "beefy red" and moist, which characterizes venous ulcers, not arterial ulcers 1
  • In the absence of neuropathy, arterial ulcers are exquisitely painful and tender to palpation, as stated by the American College of Cardiology 1
  • Pain is typically WORSE with leg elevation and IMPROVED with dependency, which is the opposite of venous disease, according to Praxis Medical Insights 2
  • Diminished or absent pulses distal to the occlusion are a key physical examination finding, as recommended by the American College of Cardiology and the Journal of the American College of Cardiology 1, 3
  • The Journal of the American College of Cardiology states that trophic changes including distal hair loss, hypertrophic nails, and shiny, atrophic skin are associated with arterial ulcers 3, 4
  • In diabetic patients with neuropathy, arterial ulcers may be painless despite severe ischemia, potentially delaying diagnosis and treatment, according to the American College of Cardiology and Diabetes/Metabolism Research and Reviews 1, 2, 6

REFERENCES

2

Vascular and Neurological Emergencies in Single Extremity Numbness [LINK]

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026