Seizure Risk with Bupropion

Recommendations to Minimize Seizure Risk

• The National Comprehensive Cancer Network recommends starting with low doses of bupropion and increasing gradually, with a titration schedule of 150 mg orally once daily for days 1-3, and 150 mg orally twice daily (maximum 300 mg per day) for day 4-12 weeks for smoking cessation 1
• The National Comprehensive Cancer Network advises avoiding bupropion in patients with risk factors for seizures, especially those with brain metastases, history of seizures, or elevated seizure risk 1

Special Considerations

• Two case reports noted seizures in breastfed infants whose mothers were taking bupropion, as reported by the American College of Obstetricians and Gynecologists 2