Combination Therapy with Atomoxetine and Stimulants for ADHD

Clinical Considerations

• The American Academy of Child and Adolescent Psychiatry recommends avoiding the use of this combination with MAO inhibitors, as it is an absolute contraindication for stimulants and would create severe hypertensive risk 2, 3, 4
• The American Academy of Child and Adolescent Psychiatry advises against using this combination in patients with active psychosis, as stimulants are contraindicated in schizophrenia and psychotic disorders 2, 3, 5
• When using combination therapy, it is essential to monitor cardiovascular parameters closely, as both medications can increase heart rate and blood pressure, and track for additive side effects, such as insomnia, decreased appetite, and mood changes, according to Praxis Medical Insights 1
• Patients requiring extended symptom control beyond what a single stimulant dose provides may benefit from combining atomoxetine with a stimulant, as stated by Praxis Medical Insights 1