Restarting Dupixent After Missing Doses

Deciding on Loading Doses Upon Restart

The American Academy of Dermatology recommends repeating loading doses if more than 3-4 half-lives have elapsed since the previous dose, which is roughly 8-16 weeks without treatment, and the patient is experiencing active disease flare, as indicated by significant worsening of atopic dermatitis, asthma, or other conditions 1, 2, 3
The decision to repeat loading doses depends on two critical factors: disease severity at restart and duration of treatment interruption, according to the American Academy of Dermatology 1, 2
Retreatment after discontinuation may result in a small percentage of patients not recapturing their previous robust response, as noted by the American Academy of Dermatology 1

Do not ignore disease flare status when deciding on restart strategy, as active flares with prolonged gaps (>8-16 weeks) warrant loading dose reinitiation rather than jumping back to maintenance, as advised by the American Academy of Dermatology 1, 2, 3
Avoid restarting during active febrile illness or infection, and wait until full resolution of symptoms and completion of any antibiotic course before resuming dupilumab, as recommended by the American Academy of Dermatology 2