Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 12/7/2025

Breastfeeding and Maternal Cholesterol Effects

Evidence on Maternal Cholesterol Effects

  • Breastfeeding is associated with reduced risk of type 2 diabetes (OR 0.68, 95% CI 0.57-0.82) and may confer longer-term metabolic benefits to mothers, including improvements in cardiovascular risk factors, according to the American Diabetes Association 1, 2.
  • The American Heart Association notes that breastfeeding may result in lower blood cholesterol levels in adults who were breastfed as infants, suggesting potential metabolic programming effects 3, 4, 5.

Important Clinical Context

  • Infant cholesterol exposure: Breastfed infants have higher cholesterol levels at 1 year of age compared to formula-fed infants, but this early exposure may paradoxically lead to lower adult cholesterol levels, as suggested by the American Heart Association 3, 4, 5.
  • Maternal cardiovascular benefits: Breastfeeding reduces maternal risks of breast cancer (OR 0.81), ovarian cancer (OR 0.70), and type 2 diabetes, suggesting overall metabolic improvements, according to the American Diabetes Association 1, 2.

Clinical Recommendations

  • All mothers, including those with diabetes, should be supported in breastfeeding attempts given the numerous maternal health benefits, including reduced cardiovascular disease risk factors, as recommended by the American Diabetes Association 1, 2, 6.
  • The immediate nutritional and immunological benefits for the infant, combined with long-term maternal metabolic advantages, strongly favor breastfeeding, according to the American Academy of Pediatrics 6, 8.

Monitoring Considerations

  • Women with pre-existing dyslipidemia or diabetes should continue appropriate monitoring during lactation, though specific cholesterol targets during breastfeeding are not established in guidelines, as noted by the American Diabetes Association 6.
  • The metabolic changes of lactation are generally favorable for long-term cardiovascular health, supporting continuation of breastfeeding when possible, according to the American Diabetes Association 1, 2.