Lisinopril Use in Patients with Impaired Renal Function and Hypertension

Efficacy and Monitoring

The Kidney Disease: Improving Global Outcomes (KDIGO) guideline recommends checking changes in blood pressure, serum creatinine, and serum potassium within 2-4 weeks of initiation or dose increase of ACE inhibitors like lisinopril, in patients with hypertension and chronic kidney disease, particularly those with albuminuria 1
ACE inhibitors like lisinopril are recommended for patients with hypertension and chronic kidney disease, particularly those with albuminuria, as they provide renoprotective effects 1

In patients with heart failure and renal impairment, lisinopril can improve cardiac function while maintaining stable renal function when properly dosed, according to the American College of Cardiology 2
ACE inhibitors have been shown to reduce remodeling after myocardial infarction and improve outcomes in patients with left ventricular dysfunction, as reported by the American Heart Association 3

Some patients may experience a transient decrease in GFR upon initiation of therapy, which is not necessarily indicative of kidney injury, as noted by the American Journal of Kidney Diseases 4
ACE inhibitors are contraindicated during pregnancy, as stated by the Kidney Disease: Improving Global Outcomes (KDIGO) guideline 1